
The protagonist, Littlepip, lives in Stable 2, alongside Velvet Remedy, a popular singer. The incorporation of more violent and mature content contributes to a darker overall tone than the Friendship Is Magic source material. Within this setting, the novel combines various cyberpunk, atompunk and retrofuturistic elements with the fantasy elements of Friendship Is Magic. The resulting conflict leaves both continents as mutant-filled wastelands, with survivors living in underground fallout shelters called "Stables". In the book, the fictional world of Equestria enters a resource war with the Zebra Empire. Fallout: Equestria places the magical ponies of the Friendship Is Magic franchise within the post-apocalyptic setting of the Fallout games. The series is a transformative fanwork, based on the Fallout video game franchise and the animated series My Little Pony: Friendship Is Magic. The book is considered to be one of the most popular My Little Pony: Friendship Is Magic fanworks, having developed a large following of its own. The book has been published as an e-book, an audiobook, and also as a physical hardcover book.

It is split into five volumes, totalling 620,000 words across more than 2,000 pages. It was originally published by anonymous user Kkat on April 12, 2011. Fallout: Equestria is a post-apocalyptic fan fiction book based on the Fallout and My Little Pony: Friendship is Magic series.
